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KMID : 0858420130150010049
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Korean Journal of Stroke
2013 Volume.15 No. 1 p.49 ~ p.56
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Impact of Post-Stroke Cognitive Impairment with No Dementia on Health-Related Quality of Life
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Park Jung-Hyun
Kim Beom-Joon
Bae Hee-Joon
Lee Ji-Sung
Lee June-Young
Han Moon-Ku
O Kyung-Yoon
Park Seong-Ho
Kang Yeon-Wook
Yu Kyung-Ho
Lee Byung-Chul
Kim Beom-Joon
Bae Hee-Joon
Lee Ji-Sung
Lee June-Young
Han Moon-Ku
Park Seong-Ho
Kang Yeon-Wook
Yu Kyung-Ho
Lee Byung-Chul
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Abstract
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Background: and Purpose Health-related quality of life (HRQoL) is a multidimensional concept that signifies a subjective evaluation of perceived health; hence, it has gained wide acceptance in geriatrics. However, its application has not been tested in patients with post-stroke cognitive impairment with no dementia (PSCIND). We investigated whether PSCIND interferes with HRQoL measured by EQ-5D, compared the findings to those of healthy people with normal cognition, and evaluated the influence of each cognitive domain on this score.
Methods: In total, 1,528 subjects were identified who had undergone neuropsychological assessment using the 60-min protocol of the Korean version of Vascular Cognitive Impairment Harmonization Standards, EQ-5D, and magnetic resonance imaging at the stroke prevention clinic. Fifty PSCIND patients were matched to 50 post-stroke dementia (PSD) patients and 50 normal age- (±3 years) and sex-matched controls. The effects of PSCIND, PSD, and control groups upon the EQ-5Dindex score were tested by generalized estimating equation modeling.
Results: Estimated means±standard errors of EQ-5Dindex scores were as follows: 0.94±0.06 (control group), 0.86±0.08 (PSCIND group), and 0.61±0.32 (PSD group); and the difference among the three groups was statistically significant (P<0.0001). Pairwise comparisons showed that EQ-5Dindex scores in the PSCIND group differed from those in the PSD and control groups (both P<0.01). No cognitive domain was specifically associated with EQ-5Dindex scores
after adjusting for functional status.
Conclusions: This study shows that PSCIND may interfere with the quality of life in stroke victims.
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KEYWORD
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Quality of life, Stroke, Dementia
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